Acner.org: Acne treatment

Acner.org: Acne treatment

Ziana and Acne

Ziana and Acne Ziana and Acne

Overview

Ziana is a topical acne medication that combines a retinoid with an antibiotic. It was approved for use in the United States in 2006, and is available only by prescription. It is another treatment option in the drug arsenal for helping the 40 to 50 million people in the United States who suffer from acne, according to Millennium CME Institute, a continuing education provider for the medical community. Topical treatments are usually tried first with acne, including topical antibiotics, topical retinoids, benzoyl peroxide or a combination of these agents, because many oral therapies have adverse effects.

Identification

Ziana is a formulation that contains 1.2 percent clindamycin phosphate, which is an antibiotic, and .025 percent tretinoin, which is a retinoid. Retinoids help combat acne by speeding up skin cell turnover. Clindamycin is used to kill Propionibacterium acnes, a bacteria associated with acne, according to Drugs.com. Ziana comes in a gel form, and is used to treat acne in people who are ages 12 and older, according to product information.

Use

To use Ziana, put a pea-sized amount of the gel on a fingertip, and dot it onto the cheeks, chin, nose and forehead. Then, gently rub the drug over the entire face, making sure to keep the gel away from the eyes, mouth, nostrils and mucous membranes, advises Medicis and Dow Pharmaceutical Sciences, Inc. The product should be applied at bedtime.

Warning

Nursing mothers, older patients and parents of children under age 12 need to discuss using Ziana with medical providers. It's unknown whether the clindamycin applied via Ziana Gel is excreted in breast milk. However, clindamycin that is taken orally or parenterally does appear in a woman's milk, and presents potential for serious adverse reactions in nursing infants. It is not known whether the other drug in Ziana, tretinoin, is excreted in breast milk. There have not been enough studies in people older than 65 to determine whether older patients respond differently than younger patients, as sometimes occurs with medication. There have been no studies that establish whether Ziana is safe for children under 12.

Side Effects

Side effects of Ziana may include scaling, burning, itching and stinging. Other adverse effects that have been reported include dry skin, sinusitis, a cough, fever, changes in skin color and stomach cramps or pain. Also, clindamycin can cause severe colitis in some people, and some who have used this drug have reported this condition, diarrhea or bloody diarrhea. Ziana should not be used by people who suffer regional enteritis, ulcerative colitis who have a history of antibiotic-related colitis, according to Medicis. People who use retinoids like tretinoin need to avoid sun exposure and wear sunscreen daily. Uncommon side effects include headaches, muscle aches and tiredness or weakness, reports the Mayo Clinic.

Considerations

People who use Ziana to treat acne need to stop using medicated or abrasive soaps and cleaners as well as any soaps or cosmetics that have a drying effect. Ziana users also need to avoid skin products that contain spices, lime, astringents or alcohol, according to Medicis.

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