Doryx & Acne
According to a 2003 report published in the Journal of the American Academy of Dermatology, acne is a common skin condition, affecting nearly 80% of people under the age of 30. A 2008 report published in Seminars in Cutaneous Medicine and Surgery estimates that United States consumers spent $2 billion in 2001on prescription anti-acne medications and up to four times that amount on nonprescription anti-acne medications. Although there are a wide variety of new medications available to acne sufferers, many dermatologists continue to prescribe Doryx, which is from a class of drugs that have been used successfully for more than 30 years for the treatment and management of acne.
Doryx is a brand name for doxycycline hyclate, a type of oral tetracycline antibiotic that is often used to treat bacterial infections, including acne. Doryx works by preventing P. acnes and Staphylococcus epidermidis, the bacteria that cause acne, from growing, and reducing skin inflammation. Doryx is taken orally and is unique in that it is the only form of doxycycline that is coated in such a way that prevents the release of the medication until it reaches the small intestine. It is approved by the United States Food and Drug Administration for the treatment of severe acne.
According to the official prescribing information for Doryx, the usual adult dose of Doryx is 100 mg every 12 hours on the first day, followed by 100 mg a day, either as one dose or 50 mg every 12 hours. Doryx should be taken with enough fluid, such as a full glass of water. Doryx can also be taken by breaking the pill and sprinkling it on applesauce, which should be eaten immediately without chewing.
Doryx and other oral antibiotics are known to cause some side effects, including gastrointestinal problems (stomach upset and diarrhea) and yeast infections. Doryx can cause tooth discoloration, and therefore should not be prescribed to pregnant women or young children. Doryx can also cause photosensitivity, or sun allergy.
Doryx can cause oral contraceptives to be less effective. Patients should not take Doryx and penicillin at the same time. Antacids containing calcium, aluminum, magnesium, iron-containing preparations or bismuth subsalicylate will affect the absorption of Doryx.
The use of antibiotics, including Doryx, can contribute to antibiotic resistance. Antibiotic resistance occurs when bacteria change in a way that makes antibiotics less effective. Ways to reduce antibiotic resistance when taking Doryx include taking all medication as prescribed and discontinuing Doryx treatment when the acne improves. The Global Alliance to Improve Outcomes in Acne recommended in 2003 that oral antibiotic therapy should be limited to 12 to 18 weeks.
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